Sancho’s low header from the edge of the area gave Dortmund the lead in the third minute.
Edin Terzic’s side had a second goal ruled out as Niclas Fullkrug was deemed offside in the build-up.
Substitute Reus capitalized on a PSV mistake deep into stoppage time to finish one-on-one against away goalkeeper Walter Benitez and settle the tie.
PSV had numerous opportunities to equalize, with Hirving Lozano particularly wasteful, and Peter Bosz’s side – who are 10 points clear at the top of the Eredivisie – were punished for their wastefulness.
Lozano, brought on as a second-half substitute, missed wide from close range, shot straight at home goalkeeper Gregor Kobel, and also missed the target from the edge of the area.
PSV’s best chance came a minute before Dortmund’s late second goal.
Luuk de Jong received a one-two but leaned back and fired over from close range as PSV’s time in the Champions League ended frustratingly.
The home side could have been ahead even earlier in the contest when Chelsea loanee Ian Maatsen’s fierce strike was tipped over by Benitez before Sancho set the tone soon after and his replacement Reus secured Dortmund’s place in the last eight with his late finish.
Sancho returned to Dortmund on loan in January and scored his first league goal since returning in a 2-1 win over Werder Bremen last weekend.
It was his 39th in the league and meant he is level with Tony Woodcock as the top English goalscorer in Bundesliga history.
The England international followed that up with his first Champions League goal since November 2021 and was named Player of the Match for his efforts.
He went off injured in the 72nd minute, seemingly with a hamstring complaint, and was replaced by Reus.
Dortmund will hope it is nothing too serious, with the youngster beginning to get back to the form he showed during his first spell in Germany.z z z z z z z z z z z z z z z z
Speaking to TNT Sports after the match, Sancho said: “Going into the game, we knew it was going to be tough but we always had the advantage because we were in front of our home fans.
“From the first whistle to the last, we stuck to our game plan and I’m just happy we got the win.
“I’m just grateful that I got the goal for the team. I’ve always got a special place for Borussia Dortmund, this is where I kind of made my name so I’ve got to be grateful to them but also to my teammates for believing in me.”
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